2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Neuropeptide Y Receptor

Neuropeptide Y Receptor

NPY receptor

Neuropeptide Y Receptor

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Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.

Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).

Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.

Neuropeptide Y Receptor Isoform Specific Products:

Neuropeptide Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1428
    RFRP-1(human)
    		Agonist 99.00%
    RFRP-1(human) is a gonadotropin-inhibitory hormone (GnIH) homolog. RFRP-1(human) targets human gonadotropin-releasing hormone (GnRH) neurons and gonadotropes and potently inhibits gonadotropin. RFRP-1(human) is a potent Neuropeptide FF (NPFF) receptor agonist with EC50s of 0.0011 nM and 29 nM for NPFF2 and NPFF1, respectively.
    RFRP-1(human)
  • HY-P1011
    Neuropeptide Y (13-36), porcine
    		Agonist 99.31%
    Neuropeptide Y (13-36), porcine is a selective neuropeptide Y2 receptor agonist.
    Neuropeptide Y (13-36), porcine
  • HY-P4060
    Pancreatic polypeptide
    		99.65%
    Pancreatic polypeptide is a peptide secreted by the endocrine PP cells of the pancreas that regulates pancreatic secretory activity and also affects hepatic glycogen stores and gastrointestinal secretion.
    Pancreatic polypeptide
  • HY-107731
    SF 11
    		Antagonist 98.76%
    SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC50=199 nM). Antidepressant-like activity.
    SF 11
  • HY-107730
    NPY5RA-972
    		Antagonist 98.99%
    NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor.
    NPY5RA-972
  • HY-P1437
    Neuropeptide S (mouse)
    		Agonist 98.83%
    Neuropeptide S (mouse) is a bioactive peptide. Neuropeptide S (mouse), as a neurotransmitter/neuromodulator of 20 amino acids, can be used for the research of arousal, anxiety, locomotion, feeding behaviors, memory and agent addiction.
    Neuropeptide S (mouse)
  • HY-P1025A
    M40 TFA
    		Modulator 98.33%
    M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas.
    M40 TFA
  • HY-P1765
    Galanin (1-19), human
    		99.25%
    Galanin (1-19), human is the 1-19 fragment of the human galanin. Galanin (GAL) is a widely distributed neuropeptide with diverse biological effects including modulation of hormone release, antinociception and modification of feeding behavior.
    Galanin (1-19), human
  • HY-P4060A
    Pancreatic polypeptide TFA
    		Agonist 99.47%
    Pancreatic polypeptide TFA is a neuropeptide Y (NPY) Y4/Y5 receptor agonist.
    Pancreatic polypeptide TFA
  • HY-107734
    L 152804
    		Antagonist 99.89%
    L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.
    L 152804
  • HY-P1322
    [D-Trp34]-Neuropeptide Y
    		Agonist 99.70%
    [D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. [D-Trp34]-Neuropeptide Y is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y markedly increases food intake in rats.
    [D-Trp34]-Neuropeptide Y
  • HY-P1578A
    Galanin (1-16), mouse, porcine, rat TFA
    		Agonist 99.92%
    Galanin (1-16), mouse, porcine, rat (TFA) is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM.
    Galanin (1-16), mouse, porcine, rat TFA
  • HY-W012999
    Tiglic acid
    		99.97%
    Tiglic acid is a monocarboxylic unsaturated organic acid. Tiglic acid can be isolated from croton oil. Tiglic acid agonizes FFA2 and upregulates PYY expression. Tiglic acid derivatives have anti-inflammatory activity. Tiglic acid can be used in the research of obesity, diabetes, and inflammatory diseases.
    Tiglic acid
  • HY-P1250
    RFRP-3(human)
    		Agonist 99.43%
    RFRP-3 (Neuropeptide VF(124-131))(human), a human GnIH peptide homolog, is a potent inhibitor of gonadotropin secretion by inhibiting Ca2+ mobilization. RFRP-3(human) is a NPFF1 receptor agonist, it inhibits forskolin-induced production of cAMP with an IC50 of 0.7 nM.
    RFRP-3(human)
  • HY-P1324
    [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide
    		Agonist 99.25%
    [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selective neuropeptide Y Y5 receptor agonist with an IC50 of 0.24 nM for binding to the hY5 receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake.
    [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide
  • HY-P0262A
    Galantide TFA
    		Antagonist 98.77%
    Galantide TFA is a reversible and non-specific galanin (GAL) receptor antagonist. Galantide TFA dose-dependently shows antagonism to galanin-induced K+ conductance with an IC50 value of 4 nM. Galantide TFA can be used for the research of neurological disease and hormone metabolism research.
    Galantide TFA
  • HY-111308
    RTI-118
    		Inhibitor 99.90%
    RTI-118 is a novel small-molecule neuropeptide S receptor (NPSR) antagonist. RTI-118 can relieve agent addiction including selectively decrease self-administration.
    RTI-118
  • HY-P3678
    Neuropeptide Y (18-36) (porcine)
    		Antagonist 98.76%
    Neuropeptide Y (18-36) (porcine) is a competitive neuropeptide Y (NPY) cardiac receptor antagonist. Neuropeptide Y (18-36) (porcine) inhibits the binding of I-NPY to cardiac ventricular membranes in a concentration-dependent manner with an IC50 value of 158 nM and an Ki value of 140 nM. Neuropeptide Y (18-36) (porcine) can be used for the research of congestive heart failure.
    Neuropeptide Y (18-36) (porcine)
  • HY-107729
    Lu AA33810
    		Antagonist 98.3%
    Lu AA33810 is a selective, orally active and brain-penetrant antagonist of neuropeptide Y5 receptor with a Ki of 1.5 nM for the rat receptor. Lu AA33810 exhibts antianxiolytic-like and antidepressant-like effects.
    Lu AA33810
  • HY-115575
    tBPC
    		Modulator 98.41%
    tBPC is a selective positive allosteric modulator for human Y4 receptor (Y4R), which enhances the activation of Y4R in G protein signaling and arrestin3 recruitment.
    tBPC
Cat. No. Product Name / Synonyms Application Reactivity
Neuropeptide Y Receptor Isoform Comparison

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